{"id":1109,"date":"2025-04-07T16:23:10","date_gmt":"2025-04-07T21:23:10","guid":{"rendered":"https:\/\/pchp.wp.vortexdev.com\/?page_id=1109"},"modified":"2026-05-13T12:37:16","modified_gmt":"2026-05-13T17:37:16","slug":"building-expertise","status":"publish","type":"page","link":"https:\/\/pchp.wp.vortexdev.com\/en\/building-expertise\/","title":{"rendered":"Building expertise"},"content":{"rendered":"\n<section class=\"wp-block-vortex-blocks-sidebar-group alignwide sidebar-group-block\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h1 class=\"wp-block-heading\">Building expertise<\/h1>\n\n\n\n<p>Together, SickKids and CHU Sainte-Justine bring complementary strengths to advance the discovery of the cause of disease, improve precision in diagnosing complex conditions, and deliver targeted treatments with greater safety and effectiveness. <\/p>\n\n\n\n<p>Part of achieving success is amplifying the next generation of change-makers through fellowships, scholarship opportunities and beyond. Read about the Precision Child Health Partnership students below.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">PCHP Students<\/h2>\n\n\n\n<p><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"sidebar-links aligndefault\"\n>\n  <ul class=\"sidebar-links__wrapper\">\n                  \n                  <li class=\"sidebar-link__wrapper\">\n            <a href=\"https:\/\/pchp.wp.vortexdev.com\/en\/research\/\" class=\"sidebar-link no-styled-link\" target=\"\">\n              <img decoding=\"async\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/themes\/pchp.ca\/dist\/images\/icons\/Research_B.svg\" alt=\"\" class=\"sidebar-link__icon\">\n              <span class=\"sidebar-link__text heading-size-5\">RESEARCH<\/span>\n                          <\/a>\n          <\/li>\n        \n              \n                  <li class=\"sidebar-link__wrapper\">\n            <a href=\"https:\/\/pchp.wp.vortexdev.com\/en\/research\/funding-opportunities\/\" class=\"sidebar-link no-styled-link\" target=\"\">\n              <img decoding=\"async\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/themes\/pchp.ca\/dist\/images\/icons\/checked_2.png\" alt=\"\" class=\"sidebar-link__icon\">\n              <span class=\"sidebar-link__text heading-size-5\">FUNDING OPPORTUNITIES<\/span>\n                          <\/a>\n          <\/li>\n        \n              \n                  <li class=\"sidebar-link__wrapper\">\n            <a href=\"https:\/\/pchp.wp.vortexdev.com\/en\/research\/on-going-projects\/\" class=\"sidebar-link no-styled-link\" target=\"\">\n              <img decoding=\"async\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/themes\/pchp.ca\/dist\/images\/icons\/OnGoingProjects_B.svg\" alt=\"\" class=\"sidebar-link__icon\">\n              <span class=\"sidebar-link__text heading-size-5\">ONGOING PROJECTS<\/span>\n                          <\/a>\n          <\/li>\n        \n              \n                  <li class=\"sidebar-link__wrapper\">\n            <a href=\"https:\/\/pchp.wp.vortexdev.com\/en\/key-terms\/\" class=\"sidebar-link no-styled-link\" target=\"\">\n              <img decoding=\"async\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/themes\/pchp.ca\/dist\/images\/icons\/KeyTerms_B.svg\" alt=\"\" class=\"sidebar-link__icon\">\n              <span class=\"sidebar-link__text heading-size-5\">KEY TERMS<\/span>\n                          <\/a>\n          <\/li>\n        \n            <\/ul>\n   \n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n<details class=\"wp-block-details alignwide has-medium-font-size is-layout-flow wp-block-details-is-layout-flow\"><summary>2025-2026<\/summary>\n<p><\/p>\n<\/details>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-3 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"1707\" height=\"2560\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-scaled.jpg\" alt=\"\" class=\"wp-image-2976\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-scaled.jpg 1707w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-200x300.jpg 200w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-683x1024.jpg 683w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-768x1152.jpg 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-1024x1536.jpg 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-1365x2048.jpg 1365w\" sizes=\"(max-width: 1707px) 100vw, 1707px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\">Dr Sa\u00efd Bichali<\/mark><\/mark><\/mark><\/mark><\/mark><\/p>\n\n\n\n<p>Metabolic and Cardiovascular Health, CHU Sainte-Justine<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong><strong><strong><strong>Impact of Clinical and Physiologic Heterogeneity on Kidney Function in Youth with Type 1 Diabetes<\/strong><\/strong><\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n\n\n\n<p class=\"has-small-font-size\">Aortic coarctation, a congenital malformation affecting approximately 1 in 2,500 individuals, is characterized by a narrowing of the aorta\u2014the vessel through which the left ventricle ejects oxygenated blood to the body. Even after surgical or catheter-based repair, persistent stiffness of the aortic wall leads to arterial hypertension in nearly 50% of patients, with consequences for left heart function. Sa\u00efd Bichali aims to establish a link between cardiac work during exercise and physical fitness (VO\u2082max, an indicator of both athletic conditioning and effective blood circulation) in children, adolescents, and young adults who have undergone repair for aortic coarctation, compared with matched controls. Cardiac work during exercise can be estimated using echocardiography and a blood pressure cuff, while VO\u2082max is measured through respiratory gas exchange during exercise testing. The ratio between left ventricular work and VO\u2082max in aortic coarctation could serve as an early indicator of cardiac dysfunction and the risk of late complications such as arrhythmias and heart failure. This project will enhance understanding of cardiac function in aortic coarctation by identifying abnormalities that become apparent during exercise rather than at rest. The findings could guide future, individualized therapeutic strategies (antihypertensive medications, re-intervention to repair the aorta, or exercise retraining) and highlight the beneficial role of physical activity in optimizing cardiac performance.<\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-3 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-5 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"641\" height=\"959\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/Headshot_AC.jpg\" alt=\"\" class=\"wp-image-2960\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/Headshot_AC.jpg 641w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/Headshot_AC-201x300.jpg 201w\" sizes=\"(max-width: 641px) 100vw, 641px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\">Antoine Clark<\/mark><\/mark><\/mark><\/mark><\/mark><\/p>\n\n\n\n<p>Translational Medicine, SickKids<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong>Impact of Clinical and Physiologic Heterogeneity on Kidney Function in Youth with Type 1 Diabetes<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\">Early signs of diabetic kidney disease (DKD) begin to emerge during adolescence and young adulthood in individuals with Type 1 Diabetes (T1D), making this a critical period for early detection and intervention. Antoine will investigate how the individual characteristics of youth with T1D influence the detection, progression, and treatment of DKD. Using a precision medicine framework, his project aims to examine factors associated with long-term trends in kidney function from adolescence to early adulthood, as well as differential responses to SGLT2i therapy, a therapy that helps block the reabsorption of sugar, according to markers such as insulin resistance and residual insulin production. Lastly, he will explore the application of machine learning algorithms to identify renal endotypes in T1D using clinical, metabolomic, proteomic, and genetic data. Together, these pillars aim to refine early detection and personalize treatment strategies for DKD in youth with T1D.&nbsp;<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-4 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-7 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"1707\" height=\"2560\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-scaled.jpg\" alt=\"\" class=\"wp-image-2978\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-scaled.jpg 1707w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-200x300.jpg 200w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-683x1024.jpg 683w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-768x1152.jpg 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-1024x1536.jpg 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-1365x2048.jpg 1365w\" sizes=\"(max-width: 1707px) 100vw, 1707px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\">Merrick Fallah<\/mark><\/mark><\/mark><\/mark><\/mark><\/mark><\/p>\n\n\n\n<p>Brain and Child Development, CHU Sainte-Justine<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong>Interneuron Transplantation for Developmental Epileptic Encephalopathies and Autism Spectrum Disorders<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\">Proper brain function relies on a finely tuned balance between neuronal excitation and inhibition, largely maintained by interneurons. Although relatively few in number, these inhibitory cells play a crucial role in modulating oscillatory activity within neural networks. Alterations in their function are implicated in several neurodevelopmental disorders, notably developmental epileptic encephalopathies and autism spectrum disorders.Merrick Fallah\u2019s project explores an innovative therapeutic approach based on the transplantation of interneuron (IN) precursors in two murine models of genetic disorders: developmental epileptic encephalopathy linked to the CACNA1A gene and autism associated with the MYO9B gene. Both models exhibit reduced interneuron populations, migration abnormalities, and impaired integration into cortical networks, leading to motor, cognitive, and behavioral deficits. By targeting a shared pathological mechanism, this project paves the way for a cross-cutting therapeutic strategy applicable to a range of disorders involving interneuron dysfunction. It could offer a new treatment perspective to improve the quality of life of affected children and their families.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-5 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-9 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"640\" height=\"951\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/Joseph-Jamnik.png\" alt=\"\" class=\"wp-image-2958\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/Joseph-Jamnik.png 640w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/Joseph-Jamnik-202x300.png 202w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\">Joseph Jamnik<\/mark><\/mark><\/mark><\/mark><\/mark><\/p>\n\n\n\n<p>Child Health Evaluative Sciences, SickKids<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong>Exploring the impact of child eating behaviours on cardiometabolic health: a longitudinal cohort study and randomized controlled trial&nbsp;<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\">Joseph\u2019s research explores how eating behaviours in early childhood impact body weight and cardiometabolic health, particularly in the context of changes observed during the COVID-19 pandemic. Conducted through the&nbsp;<a href=\"http:\/\/www.targetkids.ca\/\" target=\"_blank\" rel=\"noreferrer noopener\"><em>TARGet Kids!<\/em><\/a><em>&nbsp;<\/em>practice-based research network, his work examines the relationship between eating behaviours, body mass index, and serum lipid trajectories over time. Joseph is also working with&nbsp;<em>TARGet Kids!&nbsp;<\/em>investigators on the&nbsp;<em>Parents Together<\/em>&nbsp;<em>Trial<\/em>, an embedded network randomized controlled trial, assessing whether a virtual parenting program led by public health nurses can improve eating behaviours and other markers of child health in preschool-aged children. By integrating longitudinal observational analyses with an innovative intervention, this research will provide evidence to inform public health programs and policies aimed at preventing childhood obesity and promoting long-term cardiovascular health.&nbsp;<\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-6 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-11 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"1707\" height=\"2560\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-scaled.jpg\" alt=\"\" class=\"wp-image-2982\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-scaled.jpg 1707w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-200x300.jpg 200w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-683x1024.jpg 683w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-768x1152.jpg 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-1024x1536.jpg 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-1365x2048.jpg 1365w\" sizes=\"(max-width: 1707px) 100vw, 1707px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\">Dre Laure Lacan<\/mark><\/mark><\/mark><\/mark><\/mark><\/mark><\/mark><\/p>\n\n\n\n<p>Brain and Child Development, CHU Sainte-Justine<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong>Hemodynamic and Functional Characterization of Pediatric Cerebral Arteriovenous Malformations (AVMs): the NeuroMAV Study<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\">Cerebral arteriovenous malformations (cAVMs) are complex vascular anomalies characterized by abnormal high-flow connections between arteries and veins through a dysplastic nidus. In children, they represent the leading cause of intracerebral hemorrhage, often presenting with bleeding, higher mortality, and a greater risk of recurrence than in adults. However, risk factors identified in adults do not systematically apply to pediatric populations, and pediatric data remain limited. Moreover, the management of unruptured AVMs remains controversial due to the absence of pediatric clinical trials. The ARUBA study, which has influenced adult practice, did not include children and did not consider functional or hemodynamic parameters. This project aims to address this gap by characterizing the hemodynamic and functional profiles of ruptured and unruptured pediatric cAVMs using advanced imaging tools (4D Flow MRI, arterial spin labeling [ASL], and resting-state fMRI). This is the first project to propose an integrated approach to the pathophysiology of pediatric cAVMs. Its findings will enable the identification of biomarkers associated with rupture risk and support a personalized therapeutic approach based on imaging biomarkers rather than lesion anatomy alone.<\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-13 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"641\" height=\"957\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/headshot_ROR.jpg\" alt=\"\" class=\"wp-image-2962\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/headshot_ROR.jpg 641w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/headshot_ROR-201x300.jpg 201w\" sizes=\"(max-width: 641px) 100vw, 641px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\">Roxy H. O\u2019Rourke<\/mark><\/mark><\/mark><\/mark><\/mark><\/p>\n\n\n\n<p>Neurosciences and Mental Health, SickKids<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong>Examining social determinants of mental health in diverse Canadian children and youth&nbsp;<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\">In Canada, one in five children and youth experience mental health challenges, yet large-scale studies often rely on clinical samples that underrepresent racialized, gender-diverse, and socioeconomically marginalized populations. This gap limits understanding of how mental health symptoms manifest across intersecting social identities and contexts and may obscure disparities in access to care. Roxy\u2019s research uses the&nbsp;<a href=\"https:\/\/www.sickkids.ca\/en\/news\/archive\/2025\/spit-for-science-study-hits-40000-participant-milestone\/\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Spit for Science<\/em><\/a>&nbsp;dataset, Canada\u2019s largest community-based paediatric mental health cohort, with over 40,000 participants, to investigate how gender identity, race, ethnicity, and material deprivation interact to influence mental health traits. By focusing on traits rather than diagnoses, this work captures children and youth who may not receive formal clinical attention despite experiencing significant symptoms. The findings will generate inclusive, equity-focused evidence to inform early identification, intervention strategies, and policy reforms aimed at creating a more equitable paediatric mental health system.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<details class=\"wp-block-details alignwide has-medium-font-size is-layout-flow wp-block-details-is-layout-flow\"><summary>2024-2026<\/summary>\n<p><\/p>\n<\/details>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-8 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-15 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"1000\" height=\"1500\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/Research_Building_expertise_DGreenberg_150dpi.png\" alt=\"\" class=\"wp-image-2012\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/Research_Building_expertise_DGreenberg_150dpi.png 1000w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/Research_Building_expertise_DGreenberg_150dpi-200x300.png 200w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/Research_Building_expertise_DGreenberg_150dpi-683x1024.png 683w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/Research_Building_expertise_DGreenberg_150dpi-768x1152.png 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\">Dina Greenberg <\/mark><\/mark><\/p>\n\n\n\n<p>Developmental &amp; Stem Cell Biology, SickKids<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong>Defining mechanisms of GLI3 variant associated renal malformation in Pallister-Hall Syndrome<\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\">Congenital anomalies of the kidney and urinary tract (CAKUT) are typically genetic in origin, highly phenotypically varied, and lack genotype-phenotype correlation. This suggests that pathogenesis in monogenic CAKUT is a product of genetic variant-specific mechanisms, unique to every patient \u2013 however, no such mechanisms are presently known. Dina\u2019s work aims to fill this knowledge gap, as it hinders clinicians\u2019 diagnostic and prognostic capacities, and prevents the development of precision therapies for CAKUT.<\/p>\n\n\n\n<p class=\"has-small-font-size\">She is investigating variant-specific mechanisms that drive CAKUT in Pallister-Hall Syndrome, a rare genetic disorder that affects the development of many parts of the body. This study is the first to interrogate genotype-phenotype correlation in a monogenic form of CAKUT by characterizing a series of patient-specific genetic variants, with the aim of improving prognosis an development of precision therapies.<\/p>\n\n\n\n<p><\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-9 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-17 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"1000\" height=\"1500\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/12\/image.jpeg\" alt=\"This image has an empty alt attribute; its file name is Research_Building_expertise_DRMonnier_AGuuinic_150dpi.jpg\" class=\"wp-image-3007\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/12\/image.jpeg 1000w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/12\/image-200x300.jpeg 200w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/12\/image-683x1024.jpeg 683w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/12\/image-768x1152.jpeg 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\">Anne Monier<\/mark><\/mark><\/p>\n\n\n\n<p>Brain and Child Development,<br>CHU Sainte-Justine<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong>Synchronization of Bodies, Hearts, Brains and Lived Experiences in Autism: Social Interaction Multimodal Study contributing to Precision Diagnoses<\/strong>&nbsp;<\/p>\n\n\n\n<p class=\"has-small-font-size\">Anne Monnier\u2019s project is part of the research carried out by the Precision Psychiatry and Social Physiology laboratory, headed by Pr. Guillaume Dumas.&nbsp;<\/p>\n\n\n\n<p class=\"has-small-font-size\">It aims to enrich our understanding of autism by exploring the atypical synchronization dynamics during social interactions. This innovative research uses multi-brain and multi-body \u201chyperscanning\u201d to analyze dimensions neglected in biomedical research of autism: social interaction and lived experience. Unlike previous models which focus on individual deficits, this project suggests turning the spotlight on the dimension of interaction with others in a multimodal model which also integrates the interlocutor\u2019s dynamics. Coordination of movements, cardiac coherence, cerebral synchronization and coherence of the personal feeling of connection to others will be four modalities studied with 80 dyads of neurotypical or autistic children interacting with their parents. The aim is to determine whether a detailed characterization of these interactions, with different mechanisms, can contribute to more precision diagnoses.&nbsp;<\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-10 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-19 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"1707\" height=\"2560\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-scaled.jpg\" alt=\"\" class=\"wp-image-1436\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-scaled.jpg 1707w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-200x300.jpg 200w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-683x1024.jpg 683w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-768x1152.jpg 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-1024x1536.jpg 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-1365x2048.jpg 1365w\" sizes=\"(max-width: 1707px) 100vw, 1707px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\">Dr Amine Remita<\/mark><\/p>\n\n\n\n<p>Infectious diseases and Acute Care, CHU Sainte-Justine<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong><strong>Efficient Machine Learning Methods to discover the Determinants of Immune Protection against Cytomegalovirus Infection<\/strong><\/strong><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-small-font-size\">This research project focuses on the development of advanced machine learning and bioinformatics methods to better understand the mechanisms of immune protection against cytomegalovirus (CMV) infection, a common congenital infection and the leading cause of deafness and neurodevelopmental disorders in children. Using massive, ultra-dimensional data from cutting-edge technologies such as third-generation sequencing and phage immunoprecipitation sequencing, the team will analyze viral genomes and immune responses within well-characterized longitudinal cohorts to identify the characteristics of CMV strains capable of bypassing pre-existing immunity and causing mother-to-child transmission.<\/p>\n\n\n\n<p class=\"has-small-font-size\">This project is designing machine learning models to identify reinfections during pregnancy, to intervene and prevent fetal transmission. In addition, they aim to define mutations that enable reinfection and identify better vaccines targets among CMV variants. These efforts will help guide the development of precision vaccines that offer broad protection against multiple viral strains in mothers and children. The tools created by this project could also be adapted to other viruses, strengthening the public health response to emerging viral threats.&nbsp;<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-11 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-21 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"640\" height=\"960\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/MengqiWang2025_V3.png\" alt=\"\" class=\"wp-image-2245\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/MengqiWang2025_V3.png 640w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/MengqiWang2025_V3-200x300.png 200w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\">Mengqi Wang<\/mark><\/mark><\/p>\n\n\n\n<p>Genetics &amp; Genome Biology, SickKids<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong>Advancing molecular characterization and diagnostics of pediatric neurodevelopmental disorders through long-read sequencing<\/strong><\/p>\n\n\n\n<p class=\"has-large-font-size\"><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-small-font-size\">Mengqi\u2019s work investigates four rare pediatric neurodevelopmental disorders (NDDs) \u2013 Kabuki, CHARGE, Sotos, and Tatton-Brown-Rahman syndromes, known for their phenotypically complex and highly variable clinical presentations. These syndromes are characterized by intellectual disability, growth dysregulation, and congenital anomalies, emphasizing the crucial connection between epigenetic regulation and neurodevelopment. The clinical overlap among these syndromes presents challenges for early-life diagnosis, highlighting the need for a deeper exploration of epigenetic markers to enhance both understanding and clinical management.<\/p>\n\n\n\n<p class=\"has-small-font-size\">Previous research has successfully identified syndrome-specific DNA methylation signatures for over 60 NDDs, providing valuable insights into their pathophysiology and aiding in diagnosis. However, these findings have been constrained by the limited coverage of specific genomic regions available in the EPIC array platform. To address this limitation, this study aims to leverage long-read sequencing (LRS), an emerging technology capable of capturing both novel genomic variants and epigenomic information across the entire genome. The application of LRS will provide unprecedented insights into DNA methylation landscapes and alterations in pediatric NDDs, leading to expanded diagnostic capabilities and phenotype-epigenotype-genotype correlations. Early identification of epigenetic markers may facilitate predictive diagnostics and targeted therapeutic interventions, significantly impacting patient outcomes.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-12 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:600px\">\n<h2 class=\"wp-block-heading\">PCHP Scholars<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-13 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-24 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"300\" height=\"450\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/SK_Ashish-Deshwar.png\" alt=\"\" class=\"wp-image-1038\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/SK_Ashish-Deshwar.png 300w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/SK_Ashish-Deshwar-200x300.png 200w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\">Dr. Ashish Deshwar<\/mark><\/mark><\/p>\n\n\n\n<p>Staff Physician, Scientist-Track Investigator, SickKids<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong>Dr. Ashish Deshwar, Precision Child Health Scholar in Translational Genomics<\/strong><\/p>\n\n\n\n<p class=\"has-large-font-size\"><\/p>\n\n\n\n<p class=\"has-small-font-size\">LDr. Deshwar\u2019s research program is committed to reaching a genetic diagnosis for all children seen at the hospital through utilizing the latest technological advances and applying them to rare disease. His&nbsp;work represents the critical application of research technologies into the clinic, driving the PCH movement through three areas of interest:&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>&nbsp;<strong>Zebrafish models of new genetic diseases:&nbsp;<\/strong>In some cases, where a new potential disease gene is identified, Dr. Deshwar\u2019s group develops<strong>&nbsp;<\/strong>a zebrafish model to help describe an entirely new disease, providing a diagnosis for the patient and creating a model where you can then study the disease mechanisms and develop therapies.&nbsp;<\/li>\n\n\n\n<li><strong>Leveraging a multi-omics approach for genetic diagnosis:&nbsp;<\/strong>Using technologies like RNA sequencing and proteomics (study of proteins) to complement the DNA studies we do; we can better understand and interpret the consequence of the genetic changes seen in children.&nbsp;&nbsp;<\/li>\n\n\n\n<li><strong>Bespoke functional assays:<\/strong>&nbsp;By using established molecular biology techniques in a personalized, or \u201cbespoke\u201d fashion, we can design highly individualized tests (i.e. a test created specifically for a child seen at the hospital) to assess the impact of an individual\u2019s genetic change<\/li>\n<\/ul>\n\n\n\n<p class=\"has-small-font-size\">This work is an important prelude to the next step in a patient\u2019s journey \u2013 delivering individualized treatment. To design effective precision therapies, we first need to reveal and understand the complexity of the diagnosis.&nbsp;&nbsp;<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-14 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:600px\">\n<h2 class=\"wp-block-heading\">Training or Fellowship opportunities<\/h2>\n\n\n\n<p>The Precision Health Scholarship Program is one of the flagship initiatives of the Partnership, aimed at funding innovative research and training the next generation of researchers.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile is-image-fill-element\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Boursiers_FondationSJ_-AGuuinic-1024x683.jpg\" alt=\"\" class=\"wp-image-1420 size-full\" style=\"object-position:50% 50%\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Boursiers_FondationSJ_-AGuuinic-1024x683.jpg 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Boursiers_FondationSJ_-AGuuinic-300x200.jpg 300w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Boursiers_FondationSJ_-AGuuinic-768x512.jpg 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Boursiers_FondationSJ_-AGuuinic-1536x1024.jpg 1536w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Boursiers_FondationSJ_-AGuuinic-2048x1365.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p>The Training Program:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Will transform the discovery and development of new precision health approaches<\/li>\n\n\n\n<li>Will address the challenges related to the delivery of care to children at SickKids, CHU Sainte-Justine and beyond<\/li>\n\n\n\n<li>Will contribute to one of the three (3) main technological pillars of the Partnership, which are genomics and other omics, innovative therapies, and inter-institutional data sharing to advance precision health.<\/li>\n<\/ul>\n\n\n\n<p><strong>This program is intended for PhD students, postdoctoral fellows, and trainees holding an MD.<\/strong><\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-15 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\"><strong>Upcoming opportunities<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-buttons alignwide is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/sickkids.slideroom.com\/#\/Login\" target=\"_blank\" rel=\"noopener\">Visit Restracomp (SickKids students only)<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/recherche.chusj.org\/fr\/Etudiants\/Bourses\/Bourse-en-sante-de-precision\" target=\"_blank\" rel=\"noopener\">Bourses en sant\u00e9 de pr\u00e9cision (CHU&nbsp;Sainte-Justine&#8217;s students only)<\/a><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-vertical is-layout-flex wp-container-core-buttons-is-layout-2 wp-block-buttons-is-layout-flex\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr Sa\u00efd Bichali Metabolic and Cardiovascular Health, CHU Sainte-Justine Impact of Clinical and Physiologic Heterogeneity on Kidney Function in Youth&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1109","page","type-page","status-publish","hentry"],"acf":[],"rankMath":{"parentDomain":"wp.vortexdev.com","noFollowDomains":[],"noFollowExcludeDomains":[],"noFollowExternalLinks":false,"featuredImageNotice":"The featured image should be at least 200 by 200 pixels to be picked up by Facebook and other social media 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