{"id":32,"date":"2025-03-12T14:29:32","date_gmt":"2025-03-12T18:29:32","guid":{"rendered":"https:\/\/pchp.wp.vortexdev.com\/?page_id=32"},"modified":"2026-05-12T14:34:08","modified_gmt":"2026-05-12T19:34:08","slug":"research","status":"publish","type":"page","link":"https:\/\/pchp.wp.vortexdev.com\/en\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<section class=\"wp-block-vortex-blocks-sidebar-group alignwide sidebar-group-block\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h1 class=\"wp-block-heading\">Research<\/h1>\n\n\n\n<h3 class=\"wp-block-heading\">Azrieli Precision Child Health Platform<\/h3>\n\n\n\n<p>A transformational gift from the Azrieli Foundation, announced in late 2023, enabled the creation of the Azrieli Precision Child Health Platform. The platform represents the key work fueling the partnership, focusing on three integrated pillars of scientific activity: <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Genomics and other &#8220;Omics&#8221;, <\/li>\n\n\n\n<li>Therapies, and <\/li>\n\n\n\n<li>Data and biobanking. <\/li>\n<\/ul>\n\n\n\n<p>The platform is set to establish new standards in paediatric care, primarily through groundbreaking research, within key driver projects jointly led by SickKids and CHU Sainte-Justine. These initiatives focus on advancing evidence-based approaches that will shape the future of precision health, creating new pathways for collaboration in Canada and beyond.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"sidebar-links aligndefault\"\n>\n  <ul class=\"sidebar-links__wrapper\">\n                  \n                  <li class=\"sidebar-link__wrapper\">\n            <a href=\"https:\/\/pchp.wp.vortexdev.com\/en\/building-expertise\/\" class=\"sidebar-link no-styled-link\" target=\"\">\n              <img decoding=\"async\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/themes\/pchp.ca\/dist\/images\/icons\/Start_2.png\" alt=\"\" class=\"sidebar-link__icon\">\n              <span class=\"sidebar-link__text heading-size-5\">BUILDING EXPERTISE<\/span>\n                          <\/a>\n          <\/li>\n        \n              \n                  <li class=\"sidebar-link__wrapper\">\n            <a href=\"https:\/\/pchp.wp.vortexdev.com\/en\/research\/funding-opportunities\/\" class=\"sidebar-link no-styled-link\" target=\"\">\n              <img decoding=\"async\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/themes\/pchp.ca\/dist\/images\/icons\/checked_2.png\" alt=\"\" class=\"sidebar-link__icon\">\n              <span class=\"sidebar-link__text heading-size-5\">FUNDING OPPORTUNITIES<\/span>\n                          <\/a>\n          <\/li>\n        \n              \n                  <li class=\"sidebar-link__wrapper\">\n            <a href=\"https:\/\/pchp.wp.vortexdev.com\/en\/research\/on-going-projects\/\" class=\"sidebar-link no-styled-link\" target=\"\">\n              <img decoding=\"async\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/themes\/pchp.ca\/dist\/images\/icons\/OnGoingProjects_B.svg\" alt=\"\" class=\"sidebar-link__icon\">\n              <span class=\"sidebar-link__text heading-size-5\">ONGOING PROJECTS<\/span>\n                          <\/a>\n          <\/li>\n        \n              \n                  <li class=\"sidebar-link__wrapper\">\n            <a href=\"https:\/\/pchp.wp.vortexdev.com\/en\/key-terms\/\" class=\"sidebar-link no-styled-link\" target=\"\">\n              <img decoding=\"async\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/themes\/pchp.ca\/dist\/images\/icons\/KeyTerms_B.svg\" alt=\"\" class=\"sidebar-link__icon\">\n              <span class=\"sidebar-link__text heading-size-5\">KEY TERMS<\/span>\n                          <\/a>\n          <\/li>\n        \n            <\/ul>\n   \n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Genomics projects<\/h2>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" width=\"600\" height=\"400\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/Genome-Diagnostics-and-Cytogenetics-7JAN2024_DSC8398-1.jpg\" alt=\"\" class=\"wp-image-873 size-full\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/Genome-Diagnostics-and-Cytogenetics-7JAN2024_DSC8398-1.jpg 600w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/Genome-Diagnostics-and-Cytogenetics-7JAN2024_DSC8398-1-300x200.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">DECODE(u)R<\/h3>\n\n\n\n<p>Deploying Comprehensive Diagnostic Evaluations for Rare (and ultra rare) diseases<\/p>\n\n\n\n<p class=\"has-medium-font-size\">DECODE(u)R is a research initiative focused on increasing diagnoses of rare diseases through innovative strategies that:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li class=\"has-medium-font-size\">Enhance diagnostic methods and accelerate treatment access<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Apply and evaluate both existing and emerging genomic technologies<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Guide the integration of precision medicine approaches for rare disease care<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" width=\"1024\" height=\"717\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/Reseach_Cancer_genomics-project_iStock-1024x717.jpg\" alt=\"\" class=\"wp-image-856 size-full\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/Reseach_Cancer_genomics-project_iStock-1024x717.jpg 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/Reseach_Cancer_genomics-project_iStock-300x210.jpg 300w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/Reseach_Cancer_genomics-project_iStock-768x538.jpg 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/Reseach_Cancer_genomics-project_iStock.jpg 1224w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">Cancer Genomics Project<\/h3>\n\n\n\n<p class=\"has-medium-font-size\">The Cancer Genomics Project aims to increase the utility of genomics for childhood cancer through the adoption of new technologies. The project aims to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li class=\"has-medium-font-size\">Develop a real-time RNA-based cancer diagnostic platform<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Increase the accuracy and clinical utility of childhood tumor-normal genome sequencing<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Harmonize sample banking and clinical data curation<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div style=\"height:45px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Therapeutics projects<\/h2>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" width=\"1024\" height=\"717\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2026\/04\/tour-1-1024x717.png\" alt=\"\" class=\"wp-image-3495 size-full\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2026\/04\/tour-1-1024x717.png 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2026\/04\/tour-1-300x210.png 300w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2026\/04\/tour-1-768x538.png 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2026\/04\/tour-1.png 1224w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">PINPOINT<\/h3>\n\n\n\n<p>Preclinical Initiative for Novel PrecisiOn INdividualized Therapeutics<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><strong>PINPOINT<\/strong> is pilot study focused on developing strong pre-clinical testing pipelines to shorten the time between diagnosis and receiving individualized therapies. PINPOINT aims to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li class=\"has-medium-font-size\">Develop at lease 6 preclinical genetic medicine development programs<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Trial a pipeline for the rapid generation of patient iPSC (induced pluripotent stem) cell lines for testing of candidate therapeutics<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Develop and implement robust iPSC differentiation protocols<\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div style=\"height:45px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Data projects<\/h2>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/PSC-building-with-address-sign__DSC9598-1024x683.jpg\" alt=\"\" class=\"wp-image-2942 size-full\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/PSC-building-with-address-sign__DSC9598-1024x683.jpg 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/PSC-building-with-address-sign__DSC9598-300x200.jpg 300w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/PSC-building-with-address-sign__DSC9598-768x512.jpg 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/PSC-building-with-address-sign__DSC9598.jpg 1054w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">Expedition<\/h3>\n\n\n\n<p class=\"has-medium-font-size\">Expedition is a data initiative at SickKids focused on enhancing the discovery, sharing and analyzing of data.&nbsp; Expedition helps lay the foundation for:&nbsp;&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li class=\"has-medium-font-size\">Safe and effective data sharing and analysis <\/li>\n\n\n\n<li class=\"has-medium-font-size\">Rapid data exploration through multiple sources in a centralized and secure location <\/li>\n\n\n\n<li class=\"has-medium-font-size\">Collaborative working across study groups in different locations <\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/stock-image-1024x683.png\" alt=\"\" class=\"wp-image-2944 size-full\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/stock-image-1024x683.png 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/stock-image-300x200.png 300w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/stock-image-768x512.png 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/stock-image.png 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<h3 class=\"wp-block-heading\">UnIC<\/h3>\n\n\n\n<p>Univers Informationnel du CHU Sainte-Justine<\/p>\n\n\n\n<p class=\"has-medium-font-size\">UnIC is a digital platform launched in 2020 to secure, centralize and structure the hospital\u2019s clinical data. It consolidates information from over 30 systems within an ethical and confidential framework. The platform aims to provide researchers, clinicians, and managers with high-quality data and a powerful analytical infrastructure to support cutting-edge research, improved care, and hospital governance. In the context of digital transformation, UnIC enables:&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li class=\"has-medium-font-size\">Fast and regulated access to large-scale data; <\/li>\n\n\n\n<li class=\"has-medium-font-size\">Identification of cases for clinical trials; <\/li>\n\n\n\n<li class=\"has-medium-font-size\">Creation of dynamic cohorts and databasesl <\/li>\n\n\n\n<li class=\"has-medium-font-size\">Development of hospital monitoring tools;<\/li>\n\n\n\n<li class=\"has-medium-font-size\">Development of an automated analysis system using AI <\/li>\n<\/ul>\n<\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Genomics projects DECODE(u)R Deploying Comprehensive Diagnostic Evaluations for Rare (and ultra rare) diseases DECODE(u)R is a research initiative focused on&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-32","page","type-page","status-publish","hentry"],"acf":[],"rankMath":{"parentDomain":"wp.vortexdev.com","noFollowDomains":[],"noFollowExcludeDomains":[],"noFollowExternalLinks":false,"featuredImageNotice":"The featured image should be at least 200 by 200 pixels to be picked up by Facebook and other social media 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