{"id":1123,"date":"2025-04-07T16:23:10","date_gmt":"2025-04-07T21:23:10","guid":{"rendered":"https:\/\/pchp.wp.vortexdev.com\/building-expertise\/"},"modified":"2026-05-13T14:33:34","modified_gmt":"2026-05-13T19:33:34","slug":"former-la-releve","status":"publish","type":"page","link":"https:\/\/pchp.wp.vortexdev.com\/fr\/former-la-releve\/","title":{"rendered":"Former la rel\u00e8ve"},"content":{"rendered":"\n<section class=\"wp-block-vortex-blocks-sidebar-group alignwide sidebar-group-block\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h1 class=\"wp-block-heading\">Former la rel\u00e8ve<\/h1>\n\n\n\n<p>Ensemble, le CHU&nbsp;Sainte-Justine et le SickKids contribuent \u00e0 mieux comprendre les causes des maladies, \u00e0 raffiner le diagnostic des conditions complexes et \u00e0 proposer des traitements plus cibl\u00e9s pour les enfants.<\/p>\n\n\n\n<p>Un \u00e9l\u00e9ment essentiel de cette d\u00e9marche est de soutenir la rel\u00e8ve, en lui offrant un acc\u00e8s \u00e0 des formations de pointe, \u00e0 des bourses et \u00e0 des environnements de recherche stimulants. Vous d\u00e9couvrirez ici quelques-unes des personnes qui incarnent cette nouvelle g\u00e9n\u00e9ration et qui porteront le changement.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Bourses PCHP<\/h2>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"sidebar-links aligndefault\"\n>\n  <ul class=\"sidebar-links__wrapper\">\n                  \n                  <li class=\"sidebar-link__wrapper\">\n            <a href=\"https:\/\/pchp.wp.vortexdev.com\/fr\/recherche\/\" class=\"sidebar-link no-styled-link\" target=\"\">\n              <img decoding=\"async\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/themes\/pchp.ca\/dist\/images\/icons\/Research_B.svg\" alt=\"\" class=\"sidebar-link__icon\">\n              <span class=\"sidebar-link__text heading-size-5\">RECHERCHE<\/span>\n                          <\/a>\n          <\/li>\n        \n              \n                  <li class=\"sidebar-link__wrapper\">\n            <a href=\"https:\/\/pchp.wp.vortexdev.com\/fr\/recherche\/opportunites-de-financement\/\" class=\"sidebar-link no-styled-link\" target=\"\">\n              <img decoding=\"async\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/themes\/pchp.ca\/dist\/images\/icons\/checked_2.png\" alt=\"\" class=\"sidebar-link__icon\">\n              <span class=\"sidebar-link__text heading-size-5\">FINANCEMENTS<\/span>\n                          <\/a>\n          <\/li>\n        \n              \n                  <li class=\"sidebar-link__wrapper\">\n            <a href=\"https:\/\/pchp.wp.vortexdev.com\/fr\/recherche\/projets-en-cours\/\" class=\"sidebar-link no-styled-link\" target=\"\">\n              <img decoding=\"async\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/themes\/pchp.ca\/dist\/images\/icons\/OnGoingProjects_B.svg\" alt=\"\" class=\"sidebar-link__icon\">\n              <span class=\"sidebar-link__text heading-size-5\">PROJETS EN COURS<\/span>\n                          <\/a>\n          <\/li>\n        \n              \n                  <li class=\"sidebar-link__wrapper\">\n            <a href=\"https:\/\/pchp.wp.vortexdev.com\/fr\/termes-cles\/\" class=\"sidebar-link no-styled-link\" target=\"\">\n              <img decoding=\"async\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/themes\/pchp.ca\/dist\/images\/icons\/KeyTerms_B.svg\" alt=\"\" class=\"sidebar-link__icon\">\n              <span class=\"sidebar-link__text heading-size-5\">TERMES CL\u00c9S<\/span>\n                          <\/a>\n          <\/li>\n        \n            <\/ul>\n   \n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n<details class=\"wp-block-details alignwide has-medium-font-size is-layout-flow wp-block-details-is-layout-flow\"><summary>2025-2026<\/summary>\n<p><\/p>\n<\/details>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-3 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"1707\" height=\"2560\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-scaled.jpg\" alt=\"\" class=\"wp-image-2976\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-scaled.jpg 1707w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-200x300.jpg 200w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-683x1024.jpg 683w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-768x1152.jpg 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-1024x1536.jpg 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Said-Bichali_2025_lr-3-1365x2048.jpg 1365w\" sizes=\"(max-width: 1707px) 100vw, 1707px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\">Dr Sa\u00efd Bichali<\/mark><\/mark><\/mark><\/mark><\/mark><\/p>\n\n\n\n<p>Sant\u00e9 m\u00e9tabolique et cardiovasculaire, CHU&nbsp;Sainte-Justine<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong><strong><strong>ICoVE : Impact de la Coarctation aortique sur le travail Ventriculaire gauche \u00e0 l\u2019Effort<\/strong><\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n\n\n\n<p class=\"has-small-font-size\">La coarctation, une malformation cong\u00e9nitale affectant environ une personne sur 2500, est caract\u00e9ris\u00e9e par un r\u00e9tr\u00e9cissement de l\u2019aorte qui est le vaisseau dans lequel le ventricule gauche \u00e9jecte le sang rouge oxyg\u00e9n\u00e9 vers les organes. M\u00eame apr\u00e8s r\u00e9paration chirurgicale ou par cath\u00e9t\u00e9risme, une rigidit\u00e9 persistante de la paroi aortique entra\u00eene une hypertension art\u00e9rielle chez pr\u00e8s de 50 % des patientes et des patients, avec des cons\u00e9quences sur la fonction cardiaque gauche. Sa\u00efd Bichali cherche \u00e0 \u00e9tablir un lien entre le travail cardiaque \u00e0 l\u2019effort et l\u2019aptitude physique (VO\u2082max, indicateur du niveau d\u2019entra\u00eenement sportif ainsi que du bon fonctionnement de la circulation sanguine), chez des enfants, adolescents et jeunes adultes op\u00e9r\u00e9s d\u2019une coarctation, en les comparant \u00e0 des t\u00e9moins appari\u00e9s. Le travail cardiaque \u00e0 l\u2019effort peut \u00eatre estim\u00e9 par \u00e9chographie et brassard \u00e0 pression art\u00e9rielle. La VO2max est obtenue par les \u00e9changes gazeux respiratoires \u00e0 l\u2019effort. Le rapport entre travail du ventricule gauche et VO2max dans la coarctation aortique pourrait repr\u00e9senter un indicateur pr\u00e9coce de dysfonction cardiaque et de risque de complications tardives, telles que les arythmies et l\u2019insuffisance cardiaque. Le projet permettra de mieux comprendre le fonctionnement du c\u0153ur dans la coarctation pour d\u00e9tecter t\u00f4t les cons\u00e9quences visibles \u00e0 l\u2019effort et non au repos. Cette recherche pourrait orienter les strat\u00e9gies th\u00e9rapeutiques futures pour chaque patient (m\u00e9dicaments antihypertenseurs, r\u00e9intervention pour r\u00e9parer l\u2019aorte, r\u00e9entra\u00eenement) et souligner le r\u00f4le b\u00e9n\u00e9fique de l\u2019activit\u00e9 physique pour optimiser le travail cardiaque.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-3 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-5 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"641\" height=\"959\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/Headshot_AC.jpg\" alt=\"\" class=\"wp-image-2960\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/Headshot_AC.jpg 641w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/Headshot_AC-201x300.jpg 201w\" sizes=\"(max-width: 641px) 100vw, 641px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\">Antoine Clark<\/mark><\/mark><\/mark><\/mark><\/mark><\/p>\n\n\n\n<p>M\u00e9decine translationnelle, SickKids<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong><strong><strong>Impact de l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 clinique et physiologique sur la fonction r\u00e9nale chez les jeunes atteints de diab\u00e8te de type 1<\/strong><\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n\n\n\n<p class=\"has-small-font-size\">Les premiers signes de la maladie r\u00e9nale diab\u00e9tique (MRD) apparaissent d\u00e8s l\u2019adolescence et le d\u00e9but de l\u2019\u00e2ge adulte chez les personnes atteintes de diab\u00e8te de type 1 (DT1), faisant de cette p\u00e9riode une fen\u00eatre cruciale pour le d\u00e9pistage pr\u00e9coce et l\u2019intervention. Antoine \u00e9tudiera comment les caract\u00e9ristiques individuelles des jeunes vivant avec un DT1 influencent la d\u00e9tection, la progression et le traitement de la MRD. S\u2019appuyant sur une approche de m\u00e9decine de pr\u00e9cision, son projet vise \u00e0 analyser les facteurs associ\u00e9s \u00e0 l\u2019\u00e9volution \u00e0 long terme de la fonction r\u00e9nale, de l\u2019adolescence au d\u00e9but de l\u2019\u00e2ge adulte, ainsi que les r\u00e9ponses diff\u00e9rentielles au traitement par inhibiteurs du SGLT2 (iSGLT2), une th\u00e9rapie qui bloque la r\u00e9absorption du glucose, en fonction de marqueurs tels que la r\u00e9sistance \u00e0 l\u2019insuline et la production r\u00e9siduelle d\u2019insuline. Enfin, il explorera l\u2019utilisation d\u2019algorithmes d\u2019apprentissage automatique afin d\u2019identifier des endotypes r\u00e9naux chez les personnes atteintes de DT1 \u00e0 partir de donn\u00e9es cliniques, m\u00e9tabolomiques, prot\u00e9omiques et g\u00e9n\u00e9tiques. Ensemble, ces axes de recherche visent \u00e0 affiner le d\u00e9pistage pr\u00e9coce et \u00e0 personnaliser les strat\u00e9gies th\u00e9rapeutiques de la maladie r\u00e9nale diab\u00e9tique chez les jeunes vivant avec un diab\u00e8te de type 1.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-4 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-7 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"1707\" height=\"2560\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-scaled.jpg\" alt=\"\" class=\"wp-image-2978\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-scaled.jpg 1707w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-200x300.jpg 200w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-683x1024.jpg 683w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-768x1152.jpg 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-1024x1536.jpg 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Merrick-Fallah_2025_lr-1365x2048.jpg 1365w\" sizes=\"(max-width: 1707px) 100vw, 1707px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\">Merrick Fallah<\/mark><\/mark><\/mark><\/mark><\/mark><\/mark><\/p>\n\n\n\n<p>Cerveau et d\u00e9veloppement<br>de l\u2019enfant, CHU&nbsp;Sainte-Justine<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong><strong><strong><strong><strong>Transplantation d\u2019interneurones pour les enc\u00e9phalopathies \u00e9pileptiques d\u00e9veloppementales et les troubles du spectre de l\u2019autisme<\/strong><\/strong><\/strong><\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n\n\n\n<p class=\"has-small-font-size\">Le bon fonctionnement c\u00e9r\u00e9bral repose sur un \u00e9quilibre fin entre excitation et inhibition neuronale, assur\u00e9 en grande partie par les interneurones. Bien que peu nombreux, ces cellules inhibitrices jouent un r\u00f4le cl\u00e9 dans la modulation de l\u2019activit\u00e9 oscillatoire des r\u00e9seaux neuronaux. Des alt\u00e9rations de leur fonction sont impliqu\u00e9es dans plusieurs troubles neurod\u00e9veloppementaux, notamment les enc\u00e9phalopathies \u00e9pileptiques d\u00e9veloppementales et les troubles du spectre de l\u2019autisme. Le projet de Merrick Fallah explore une approche th\u00e9rapeutique innovante bas\u00e9e sur la transplantation de pr\u00e9curseurs d\u2019IN dans deux mod\u00e8les murins de pathologies g\u00e9n\u00e9tiques : l\u2019enc\u00e9phalopathie \u00e9pileptique d\u00e9veloppementale li\u00e9e au g\u00e8ne CACNA1A et l\u2019autisme associ\u00e9 au g\u00e8ne MYO9B. Ces deux mod\u00e8les pr\u00e9sentent une r\u00e9duction des populations d\u2019interneurones, des anomalies de migration et une int\u00e9gration d\u00e9ficiente dans les r\u00e9seaux corticaux, entra\u00eenant des troubles moteurs, cognitifs et comportementaux. En ciblant un m\u00e9canisme pathologique commun, ce projet ouvre la voie \u00e0 une strat\u00e9gie th\u00e9rapeutique transversale pour de nombreux troubles li\u00e9s \u00e0 la dysfonction des interneurones. Il pourrait ainsi offrir une nouvelle perspective de traitement pour am\u00e9liorer la qualit\u00e9 de vie des enfants atteints de ces maladies, ainsi que celle de leurs familles.<\/p>\n\n\n\n<p><\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-5 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-9 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"640\" height=\"951\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/Joseph-Jamnik.png\" alt=\"\" class=\"wp-image-2958\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/Joseph-Jamnik.png 640w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/Joseph-Jamnik-202x300.png 202w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\">Joseph Jamnik<\/mark><\/mark><\/mark><\/mark><\/mark><\/p>\n\n\n\n<p>Sciences \u00e9valuatives en sant\u00e9 de l\u2019enfant, SickKids<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong><strong><strong><strong>Impact des comportements alimentaires des enfants sur la sant\u00e9 cardiom\u00e9tabolique : \u00e9tude de cohorte longitudinale et essai contr\u00f4l\u00e9 randomis\u00e9<\/strong><\/strong><\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n\n\n\n<p class=\"has-small-font-size\">Les travaux de Joseph portent sur l\u2019influence des comportements alimentaires au d\u00e9but de l\u2019enfance sur le poids corporel et la sant\u00e9 cardiom\u00e9tabolique, notamment dans le contexte des changements observ\u00e9s durant la pand\u00e9mie de COVID-19. Men\u00e9e au sein du r\u00e9seau de recherche en pratique TARGet Kids!, son \u00e9tude examine, au fil du temps, les liens entre les comportements alimentaires, l\u2019indice de masse corporelle et l\u2019\u00e9volution des lipides s\u00e9riques. Joseph collabore \u00e9galement avec les chercheuses et chercheurs de <a href=\"https:\/\/www.targetkids.ca\/\" target=\"_blank\" rel=\"noopener\">TARGet Kids!<\/a> dans le cadre de l\u2019essai <em>Parents Together<\/em>, un essai contr\u00f4l\u00e9 randomis\u00e9 int\u00e9gr\u00e9 au r\u00e9seau, visant \u00e0 \u00e9valuer si un programme virtuel de soutien \u00e0 la parentalit\u00e9, anim\u00e9 par des infirmi\u00e8res de sant\u00e9 publique, peut am\u00e9liorer les comportements alimentaires et d\u2019autres indicateurs de sant\u00e9 chez les enfants d\u2019\u00e2ge pr\u00e9scolaire. En combinant des analyses observationnelles longitudinales \u00e0 une intervention novatrice, ce projet de recherche g\u00e9n\u00e9rera des donn\u00e9es probantes pour orienter les programmes et les politiques de sant\u00e9 publique destin\u00e9s \u00e0 pr\u00e9venir l\u2019ob\u00e9sit\u00e9 infantile et \u00e0 favoriser une sant\u00e9 cardiovasculaire durable.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-6 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-11 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"1707\" height=\"2560\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-scaled.jpg\" alt=\"\" class=\"wp-image-2982\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-scaled.jpg 1707w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-200x300.jpg 200w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-683x1024.jpg 683w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-768x1152.jpg 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-1024x1536.jpg 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/11\/Portrait_Laure-Lacan_2025_lr-1365x2048.jpg 1365w\" sizes=\"(max-width: 1707px) 100vw, 1707px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\">Dre Laure Lacan<\/mark><\/mark><\/mark><\/mark><\/mark><\/mark><\/mark><\/p>\n\n\n\n<p>Cerveau et d\u00e9veloppement<br>de l\u2019enfant, CHU&nbsp;Sainte-Justine<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong><strong><strong><strong><strong><strong><strong>Caract\u00e9risation h\u00e9modynamique et fonctionnelle des malformations art\u00e9rioveineuses (MAV) c\u00e9r\u00e9brales p\u00e9diatriques : \u00e9tude NeuroMAV<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n\n\n\n<p class=\"has-small-font-size\">Les malformations art\u00e9rio-veineuses c\u00e9r\u00e9brales (MAVc) sont des anomalies vasculaires complexes, caract\u00e9ris\u00e9es par des connexions anormales \u00e0 haut d\u00e9bit entre art\u00e8res et veines via un nidus dysplasique. Chez l\u2019enfant, elles repr\u00e9sentent la principale cause d\u2019h\u00e9morragie intrac\u00e9r\u00e9brale, avec une pr\u00e9sentation souvent h\u00e9morragique, une mortalit\u00e9 accrue et un risque de r\u00e9cidive plus \u00e9lev\u00e9 que chez l\u2019adulte. Cependant, les facteurs de risque identifi\u00e9s chez l\u2019adulte ne s\u2019appliquent pas syst\u00e9matiquement \u00e0 l\u2019enfant, et les donn\u00e9es p\u00e9diatriques restent limit\u00e9es. De plus, la prise en charge des MAV non rompues demeure controvers\u00e9e, en l\u2019absence d\u2019essais cliniques p\u00e9diatriques. L\u2019\u00e9tude ARUBA, qui a influenc\u00e9 les pratiques chez l\u2019adulte, n\u2019incluait pas d\u2019enfants et ne tenait pas compte des param\u00e8tres fonctionnels ou h\u00e9modynamiques. Ce projet vise \u00e0 combler cette lacune en caract\u00e9risant les profils h\u00e9modynamiques et fonctionnels des MAV rompues et non rompues chez l\u2019enfant \u00e0 l\u2019aide d\u2019outils d\u2019imagerie avanc\u00e9e (IRM 4D Flow, ASL, IRMf au repos). Ce projet est le premier \u00e0 proposer une approche int\u00e9gr\u00e9e de la physiopathologie des MAVc p\u00e9diatriques. Ses r\u00e9sultats permettront d\u2019identifier des biomarqueurs de risque de rupture, et de proposer une approche th\u00e9rapeutique personnalis\u00e9e, fond\u00e9e sur l\u2019imagerie plut\u00f4t que sur la seule anatomie l\u00e9sionnelle.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-13 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"641\" height=\"957\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/headshot_ROR.jpg\" alt=\"\" class=\"wp-image-2962\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/headshot_ROR.jpg 641w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/10\/headshot_ROR-201x300.jpg 201w\" sizes=\"(max-width: 641px) 100vw, 641px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\"><mark class=\"anton-font\">Roxy H. O\u2019Rourke<\/mark><\/mark><\/mark><\/mark><\/mark><\/p>\n\n\n\n<p>Neurosciences et sant\u00e9 mentale, SickKids<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong><strong><strong><strong>D\u00e9terminants sociaux de la sant\u00e9 mentale chez des enfants et des jeunes canadiens issus de la diversit\u00e9<\/strong><\/strong><\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n\n\n\n<p class=\"has-small-font-size\">Au Canada, un enfant ou un jeune sur cinq vit avec des enjeux de sant\u00e9 mentale. Pourtant, les \u00e9tudes \u00e0 grande \u00e9chelle reposent souvent sur des \u00e9chantillons cliniques qui sous-repr\u00e9sentent les populations racis\u00e9es, les personnes de diversit\u00e9 de genre et celles issues de milieux socio\u00e9conomiques marginalis\u00e9s. Cette lacune limite la compr\u00e9hension de la mani\u00e8re dont les sympt\u00f4mes en sant\u00e9 mentale se manifestent \u00e0 l\u2019intersection de diff\u00e9rentes identit\u00e9s sociales et contextes de vie, et peut masquer des in\u00e9galit\u00e9s dans l\u2019acc\u00e8s aux soins. Les travaux de Roxy s\u2019appuient sur la cohorte <em><a href=\"https:\/\/www.sickkids.ca\/en\/news\/archive\/2025\/spit-for-science-study-hits-40000-participant-milestone\/\" target=\"_blank\" rel=\"noopener\">Spit for Science<\/a><\/em>, le plus vaste ensemble de donn\u00e9es communautaires en sant\u00e9 mentale p\u00e9diatrique au Canada, regroupant plus de 40 000 participantes et participants. Sa recherche vise \u00e0 comprendre comment l\u2019identit\u00e9 de genre, la race, l\u2019ethnicit\u00e9 et la privation mat\u00e9rielle interagissent pour influencer les traits de sant\u00e9 mentale. En mettant l\u2019accent sur les traits plut\u00f4t que sur les diagnostics, cette approche permet d\u2019inclure des enfants et des jeunes qui ne re\u00e7oivent pas n\u00e9cessairement de suivi clinique formel malgr\u00e9 la pr\u00e9sence de sympt\u00f4mes significatifs. Les r\u00e9sultats g\u00e9n\u00e9reront des donn\u00e9es probantes inclusives, ancr\u00e9es dans une perspective d\u2019\u00e9quit\u00e9, afin d\u2019\u00e9clairer le d\u00e9pistage pr\u00e9coce, les strat\u00e9gies d\u2019intervention et les r\u00e9formes des politiques publiques, dans l\u2019objectif de b\u00e2tir un syst\u00e8me de sant\u00e9 mentale p\u00e9diatrique plus \u00e9quitable.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<details class=\"wp-block-details alignwide has-medium-font-size is-layout-flow wp-block-details-is-layout-flow\"><summary>2024-2025<\/summary>\n<p><\/p>\n<\/details>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-8 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-15 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"1000\" height=\"1500\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/Research_Building_expertise_DGreenberg_150dpi.png\" alt=\"\" class=\"wp-image-2012\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/Research_Building_expertise_DGreenberg_150dpi.png 1000w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/Research_Building_expertise_DGreenberg_150dpi-200x300.png 200w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/Research_Building_expertise_DGreenberg_150dpi-683x1024.png 683w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/Research_Building_expertise_DGreenberg_150dpi-768x1152.png 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\">Dina Greenberg <\/mark><\/mark><\/p>\n\n\n\n<p>Biologie du d\u00e9veloppement et des cellules souches, SickKids<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong><strong>D\u00e9finition des m\u00e9canismes de la malformation r\u00e9nale associ\u00e9e \u00e0 la variante GLI3 dans le syndrome de Pallister-Hall<\/strong><\/strong><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-small-font-size\">Les anomalies cong\u00e9nitales des reins et des voies urinaires (CAKUT) sont g\u00e9n\u00e9ralement d\u2019origine g\u00e9n\u00e9tique, pr\u00e9sentent une grande variabilit\u00e9 ph\u00e9notypique et ne montrent pas de corr\u00e9lation claire entre le g\u00e9notype et le ph\u00e9notype. Cela sugg\u00e8re que la pathogen\u00e8se des CAKUT monog\u00e9niques r\u00e9sulte de m\u00e9canismes sp\u00e9cifiques \u00e0 chaque variante g\u00e9n\u00e9tique, propres \u00e0 chaque patient \u2013 cependant, aucun de ces m\u00e9canismes n\u2019est actuellement connu. Le travail de Dina vise \u00e0 combler cette lacune, qui limite les capacit\u00e9s diagnostiques et pronostiques des cliniciens, et emp\u00eache le d\u00e9veloppement de th\u00e9rapies de pr\u00e9cision pour les CAKUT. Elle \u00e9tudie les m\u00e9canismes sp\u00e9cifiques aux variantes provoquant ces derni\u00e8res dans le syndrome de Pallister-Hall, une maladie g\u00e9n\u00e9tique rare affectant le d\u00e9veloppement de nombreuses parties du corps. Cette \u00e9tude est la premi\u00e8re \u00e0 explorer la corr\u00e9lation g\u00e9notype-ph\u00e9notype dans une forme monog\u00e9nique de CAKUT en caract\u00e9risant une s\u00e9rie de variantes g\u00e9n\u00e9tiques propres \u00e0 chaque patient, dans le but d\u2019am\u00e9liorer le pronostic et de d\u00e9velopper des th\u00e9rapies de pr\u00e9cision.<\/p>\n\n\n\n<p><\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-9 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-17 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"1000\" height=\"1500\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/12\/image.jpeg\" alt=\"This image has an empty alt attribute; its file name is Research_Building_expertise_DRMonnier_AGuuinic_150dpi.jpg\" class=\"wp-image-3007\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/12\/image.jpeg 1000w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/12\/image-200x300.jpeg 200w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/12\/image-683x1024.jpeg 683w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/12\/image-768x1152.jpeg 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\">Anne Monier<\/mark><\/mark><\/p>\n\n\n\n<p>Cerveau et d\u00e9veloppement<br>de l\u2019enfant, CHU&nbsp;Sainte-Justine<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong><strong>Synchronisation des corps, c\u0153urs, cerveaux et exp\u00e9riences v\u00e9cues en autisme&nbsp;: \u00e9tude multimodale de l\u2019interaction sociale pour contribuer aux diagnostics de pr\u00e9cision<\/strong><\/strong><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-small-font-size\">Anne Monnier pr\u00e9cise que son doctorat s\u2019inscrit dans le cadre des recherches men\u00e9es par le laboratoire de Psychiatrie de Pr\u00e9cision et de Physiologie Sociale, dirig\u00e9 par le Pr. Guillaume Dumas. Il vise \u00e0 enrichir la compr\u00e9hension de l\u2019autisme en explorant les dynamiques atypiques de synchronisation lors des interactions sociales. Cette recherche novatrice utilise l\u2019hyperscanning&nbsp;multi-cerveaux et multi-corps pour analyser des dimensions n\u00e9glig\u00e9es dans les \u00e9tudes biom\u00e9dicales sur l\u2019autisme : l\u2019interaction sociale et l\u2019exp\u00e9rience v\u00e9cue. Contrairement aux anciens mod\u00e8les qui se concentrent sur des d\u00e9ficits individuels, ce projet propose de tourner le projecteur sur la dimension de l\u2019interaction \u00e0 autrui dans un mod\u00e8le multimodal qui int\u00e8gre aussi la dynamique de l\u2019interlocuteur. La coordination des mouvements, la coh\u00e9rence cardiaque, la synchronisation c\u00e9r\u00e9brale et la coh\u00e9rence du sentiment personnel de connexion \u00e0 l\u2019autre seront quatre modalit\u00e9s \u00e9tudi\u00e9es avec 80 dyades d\u2019enfants neurotypiques ou autistes en interaction avec leurs parents. L\u2019objectif est de d\u00e9terminer si une caract\u00e9risation fine de ces interactions aux m\u00e9canismes diff\u00e9rents peut contribuer \u00e0 des diagnostics plus pr\u00e9cis.<\/p>\n\n\n\n<p class=\"has-small-font-size\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-10 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-19 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"1707\" height=\"2560\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-scaled.jpg\" alt=\"\" class=\"wp-image-1436\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-scaled.jpg 1707w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-200x300.jpg 200w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-683x1024.jpg 683w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-768x1152.jpg 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-1024x1536.jpg 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Building_expertise_DRRemita_AGuuinic_150dpi-1365x2048.jpg 1365w\" sizes=\"(max-width: 1707px) 100vw, 1707px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\">Dr Amine Remita<\/mark><\/p>\n\n\n\n<p>Maladies infectieuses et soins aigus, CHU&nbsp;Sainte-Justine<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong>M\u00e9thodes efficaces d&rsquo;apprentissage automatique pour d\u00e9couvrir les d\u00e9terminants de la protection immunitaire contre l&rsquo;infection par le cytom\u00e9galovirus<\/strong><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-small-font-size\">Ce projet de recherche se concentre sur le d\u00e9veloppement de m\u00e9thodes avanc\u00e9es d&rsquo;apprentissage automatique et de bio-informatique pour mieux comprendre les m\u00e9canismes de protection immunitaire contre l&rsquo;infection par le cytom\u00e9galovirus (CMV), une infection cong\u00e9nitale courante et la principale cause de surdit\u00e9 et de troubles neurod\u00e9veloppementaux chez les enfants. En utilisant des donn\u00e9es massives et ultra-dimensionnelles issues de technologies de pointe telles que le s\u00e9quen\u00e7age de troisi\u00e8me g\u00e9n\u00e9ration et le s\u00e9quen\u00e7age par immunopr\u00e9cipitation de phages, nous analyserons les g\u00e9nomes viraux et les r\u00e9ponses immunitaires au sein de cohortes longitudinales bien caract\u00e9ris\u00e9es afin d&rsquo;identifier les caract\u00e9ristiques des souches de CMV capables de contourner l&rsquo;immunit\u00e9 pr\u00e9existante et de provoquer une transmission m\u00e8re-enfant. Nous concevons des mod\u00e8les d&rsquo;apprentissage automatique pour identifier les r\u00e9infections pendant la grossesse, afin d&rsquo;intervenir pour pr\u00e9venir la transmission f\u0153tale. De plus, nous visons \u00e0 d\u00e9finir des mutations qui permettent la r\u00e9infection et \u00e0 identifier de meilleures cibles vaccinales parmi les variants du CMV. Ces efforts contribueront \u00e0 orienter le d\u00e9veloppement de vaccins de pr\u00e9cision qui offrent une large protection contre de multiples souches virales chez les m\u00e8res et les enfants. Les outils cr\u00e9\u00e9s dans ce projet pourraient \u00e9galement \u00eatre adapt\u00e9s \u00e0 d&rsquo;autres virus, renfor\u00e7ant ainsi la r\u00e9ponse de sant\u00e9 publique face aux menaces virales \u00e9mergentes.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-11 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-21 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"640\" height=\"960\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/MengqiWang2025_V3.png\" alt=\"\" class=\"wp-image-2245\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/MengqiWang2025_V3.png 640w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/06\/MengqiWang2025_V3-200x300.png 200w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\">Mengqi Wang<\/mark><\/mark><\/p>\n\n\n\n<p>G\u00e9n\u00e9tique et biologie du g\u00e9nome, SickKids<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong><strong>Faire progresser la caract\u00e9risation mol\u00e9culaire et le diagnostic des troubles neurod\u00e9veloppementaux p\u00e9diatriques gr\u00e2ce au s\u00e9quen\u00e7age \u00e0 lecture longue<\/strong><\/strong><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p class=\"has-small-font-size\">Le travail de Mengqi porte sur quatre troubles neurod\u00e9veloppementaux p\u00e9diatriques rares (TND) \u2013 les syndromes de Kabuki, CHARGE, Sotos et Tatton-Brown-Rahman \u2013 connus pour leurs pr\u00e9sentations cliniques complexes et tr\u00e8s variables. Ces syndromes se caract\u00e9risent par une d\u00e9ficience intellectuelle, une dysr\u00e9gulation de la croissance et des anomalies cong\u00e9nitales, soulignant le lien crucial entre la r\u00e9gulation \u00e9pig\u00e9n\u00e9tique et le neurod\u00e9veloppement. Le chevauchement clinique entre ces syndromes complique le diagnostic pr\u00e9coce, ce qui met en \u00e9vidence la n\u00e9cessit\u00e9 d\u2019explorer plus en profondeur les marqueurs \u00e9pig\u00e9n\u00e9tiques afin d\u2019am\u00e9liorer la compr\u00e9hension et la prise en charge clinique. Des recherches ant\u00e9rieures ont permis d\u2019identifier avec succ\u00e8s des signatures de m\u00e9thylation de l\u2019ADN sp\u00e9cifiques \u00e0 plus de 60 TND, fournissant des informations pr\u00e9cieuses sur leur physiopathologie et facilitant le diagnostic. Cependant, ces d\u00e9couvertes ont \u00e9t\u00e9 limit\u00e9es par la couverture restreinte de certaines r\u00e9gions g\u00e9nomiques offerte par la plateforme EPIC array. Pour surmonter cette limitation, cette \u00e9tude vise \u00e0 exploiter le s\u00e9quen\u00e7age \u00e0 lecture longue, une technologie \u00e9mergente capable de d\u00e9tecter \u00e0 la fois de nouvelles variantes g\u00e9nomiques et des informations \u00e9pig\u00e9nomiques \u00e0 l\u2019\u00e9chelle du g\u00e9nome entier. L\u2019application du s\u00e9quen\u00e7age \u00e0 lecture longue offrira des perspectives in\u00e9dites sur les paysages de m\u00e9thylation de l\u2019ADN et leurs alt\u00e9rations dans les TND p\u00e9diatriques, permettant d\u2019\u00e9largir les capacit\u00e9s diagnostiques et de mieux corr\u00e9ler ph\u00e9notype, \u00e9pig\u00e9nome et g\u00e9nome. L\u2019identification pr\u00e9coce de marqueurs \u00e9pig\u00e9n\u00e9tiques pourrait faciliter un diagnostic pr\u00e9dictif et des interventions th\u00e9rapeutiques cibl\u00e9es, avec un impact significatif sur la sant\u00e9 des patients.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-12 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Chercheuses et chercheurs boursiers<\/h2>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-13 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column releve-left-col is-content-justification-left is-layout-constrained wp-container-core-column-is-layout-24 wp-block-column-is-layout-constrained\" style=\"flex-basis:20%\">\n<figure class=\"wp-block-image size-full is-resized is-style-rounded img-releve\"><img decoding=\"async\" width=\"300\" height=\"450\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/SK_Ashish-Deshwar.png\" alt=\"\" class=\"wp-image-1038\" style=\"width:auto;height:375px\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/SK_Ashish-Deshwar.png 300w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/04\/SK_Ashish-Deshwar-200x300.png 200w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/figure>\n\n\n\n<p class=\"has-medium-font-size\"><mark class=\"anton-font\"><mark class=\"anton-font\">Dr. Ashish Deshwar<\/mark><\/mark><\/p>\n\n\n\n<p>Physicien, Scientifique-Chercheur, SickKids<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:80%\">\n<p class=\"has-large-font-size\"><strong><strong><strong>Dr. Ashish Deshwar, chercheur en sant\u00e9 p\u00e9diatrique de pr\u00e9cision et g\u00e9nomique translationnelle<\/strong><\/strong><\/strong><\/p>\n\n\n\n<p class=\"has-small-font-size\">Le programme de recherche du Dr. Deshwar vise \u00e0 \u00e9tablir un diagnostic g\u00e9n\u00e9tique pour tous les enfants vus \u00e0 l\u2019h\u00f4pital, en utilisant les derni\u00e8res avanc\u00e9es technologiques et en les appliquant aux maladies rares. Son travail repr\u00e9sente l&rsquo;application tant attendue des technologies de recherche en milieu clinique, soutenant le mouvement de sant\u00e9 de pr\u00e9cision p\u00e9diatrique \u00e0 travers trois axes principaux :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mod\u00e8les de maladies g\u00e9n\u00e9tiques chez le poisson-z\u00e8bre :<\/strong> lorsqu&rsquo;un nouveau g\u00e8ne potentiellement li\u00e9 \u00e0 une maladie est identifi\u00e9, la communaut\u00e9 scientifique aura la possibilit\u00e9 dans certains cas d&rsquo;utiliser un mod\u00e8le poisson-z\u00e8bre afin de repr\u00e9senter une toute nouvelle maladie. Cela permet d\u2019\u00e9tablir un diagnostic pour la patiente ou le patient, d\u2019\u00e9tudier les m\u00e9canismes de la maladie et de d\u00e9velopper des th\u00e9rapies \u00e0 partir de ce nouveau mod\u00e8le.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Approche multi-omique pour le diagnostic g\u00e9n\u00e9tique :<\/strong> en utilisant des technologies comme le s\u00e9quen\u00e7age ARN et la prot\u00e9omique (\u00e9tude des prot\u00e9ines) en compl\u00e9ment des analyses ADN, la communaut\u00e9 scientifique pourra mieux comprendre et interpr\u00e9ter les cons\u00e9quences des alt\u00e9rations g\u00e9n\u00e9tiques observ\u00e9es chez les enfants.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Analyses fonctionnelles personnalis\u00e9es<\/strong> <strong>:<\/strong> gr\u00e2ce \u00e0 des techniques de biologie mol\u00e9culaire \u00e9tablies, utilis\u00e9es de mani\u00e8re personnalis\u00e9e (\u00ab sur mesure \u00bb), la communaut\u00e9 scientifique aura la possibilit\u00e9 de concevoir des tests hautement individualis\u00e9s (c\u2019est-\u00e0-dire un test cr\u00e9\u00e9 sp\u00e9cifiquement pour un enfant vu \u00e0 l\u2019h\u00f4pital) afin d\u2019\u00e9valuer l\u2019impact d\u2019une variation g\u00e9n\u00e9tique propre \u00e0 cet individu.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-small-font-size\">Son travail constitue une \u00e9tape cruciale avant la prochaine phase du parcours de la patiente ou du patient : la mise en place de traitements individualis\u00e9s. Afin de concevoir des th\u00e9rapies de pr\u00e9cision efficaces, il est d\u2019abord n\u00e9cessaire de d\u00e9montrer et de comprendre la complexit\u00e9 du diagnostic.<\/p>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-group alignwide is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-2 wp-block-group-is-layout-constrained\">\n<h2 class=\"wp-block-heading\">La rel\u00e8ve \u00e9tudiante<\/h2>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-14 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50.01%\">\n<p>Le programme de bourses en sant\u00e9 de pr\u00e9cision est l\u2019une des initiatives phares du partenariat. Il vise \u00e0 financer des recherches novatrices et \u00e0 former la prochaine g\u00e9n\u00e9ration de chercheurs.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignwide is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-media-text alignwide is-stacked-on-mobile is-image-fill-element\"><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Boursiers_FondationSJ_-AGuuinic-1024x683.jpg\" alt=\"\" class=\"wp-image-1421 size-full\" style=\"object-position:50% 50%\" srcset=\"https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Boursiers_FondationSJ_-AGuuinic-1024x683.jpg 1024w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Boursiers_FondationSJ_-AGuuinic-300x200.jpg 300w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Boursiers_FondationSJ_-AGuuinic-768x512.jpg 768w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Boursiers_FondationSJ_-AGuuinic-1536x1024.jpg 1536w, https:\/\/pchp.wp.vortexdev.com\/wp-content\/uploads\/2025\/05\/Research_Boursiers_FondationSJ_-AGuuinic-2048x1365.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p>Ce programme :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>transformera la d\u00e9couverte et le d\u00e9veloppement de nouvelles approches en sant\u00e9 de pr\u00e9cision&nbsp;;<\/li>\n\n\n\n<li>r\u00e9pondra aux d\u00e9fis li\u00e9s \u00e0 la prestation de soins aux enfants du CHU&nbsp;Sainte-Justine et du SickKids et au-del\u00e0&nbsp;;<\/li>\n\n\n\n<li>contribuera aux trois piliers technologiques principaux du partenariat : g\u00e9nomique et autres omiques, th\u00e9rapies innovantes et partage interinstitutionnel des donn\u00e9es pour faire progresser la sant\u00e9 de pr\u00e9cision.<\/li>\n<\/ul>\n\n\n\n<p><strong>Ce programme s\u2019adresse aux \u00e9tudiantes et \u00e9tudiants au doctorat, aux chercheuses et chercheurs postdoctoraux et aux stagiaires titulaires d\u2019un dipl\u00f4me en m\u00e9decine (MD).<\/strong><\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-small-font-size\">\u00a9 CHU&nbsp;Sainte-Justine <\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-15 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div style=\"height:72px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Prochaines opportunit\u00e9s :<\/strong><\/h2>\n\n\n\n<div class=\"wp-block-buttons alignwide is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/sickkids.slideroom.com\/#\/Login\" target=\"_blank\" rel=\"noopener\">Visitez Restracomp (\u00e9tudiantes et \u00e9tudiants du SickKids seulement)<\/a><\/div>\n\n\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/recherche.chusj.org\/fr\/Etudiants\/Bourses\/Bourse-en-sante-de-precision\" target=\"_blank\" rel=\"noopener\">Bourses en sant\u00e9 de pr\u00e9cision (\u00e9tudiantes et \u00e9tudiants du CHU&nbsp;Sainte-Justine uniquement)<\/a><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr Sa\u00efd Bichali Sant\u00e9 m\u00e9tabolique et cardiovasculaire, CHU&nbsp;Sainte-Justine ICoVE : Impact de la Coarctation aortique sur le travail Ventriculaire gauche&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1123","page","type-page","status-publish","hentry"],"acf":[],"rankMath":{"parentDomain":"wp.vortexdev.com","noFollowDomains":[],"noFollowExcludeDomains":[],"noFollowExternalLinks":false,"featuredImageNotice":"The featured image should be at least 200 by 200 pixels to be picked up by Facebook and other social media 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